Patterns of disease relapse and posttreatment follow-up of patients with resected pancreatic adenocarcinoma: A single-center analysis.

BACKGROUND AND OBJECTIVES: To describe the patterns of disease relapse and follow-up of patients with resected pancreatic adenocarcinoma. Additionally, we looked at patients' characteristics at relapse and survival. METHODS: We included patients with potentially resectable pancreatic adenocarcinoma diagnosed from 2008 to 2018 who were submitted to resection with clear macroscopic margins and started posttreatment surveillance. RESULTS: The study population consists of 73 patients. The median interval between imaging studies was 3.2 months during the first 2 years of follow-up and 5.1 months thereafter. Forty-eight patients (65.8%) experienced disease relapse. The most frequent single site of relapse was locoregional (N = 21; 43.8%). At relapse, 31 patients (64.6%) were symptomatic and forty-two patients (87.6%) had Eastern Cooperative Oncology Group performance status 0 or 1. Most patients were able to undergo additional anticancer therapy (N = 41; 85.4%). Patients with asymptomatic relapses experienced longer median postrelapse survival (25.4 vs. 11.3 months; p = 0.015). CONCLUSIONS: A follow-up protocol that included imaging studies every 3 months in the first 2 years and every 6 months thereafter is able to diagnose disease relapse when patients have adequate performance status and are still able to undergo additional anticancer treatment.

Lesiones no intencionales en menores de 18 años / Unintentional Injuries in Children under Eighteen Years of Age

Introducción: Las lesiones no intencionales se consideran un problema de salud en el mundo, las tasas se elevan de forma marcada. En Cuba ocupan una de las primeras causas de morbilidad en la edad pediátrica. Objetivo: Describir las principales características epidemiológicas de las lesiones no intencionales en menores de 18 años en Matanzas. Métodos: Se realizó un estudio descriptivo en Matanzas entre el 2013 y el 2018. El universo estuvo constituido por las 4464 lesiones no intencionales ocurridas en menores de 18 años durante el periodo analizado. Para el análisis de las variables se utilizaron tasas crudas por 10 000 habitantes. Resultados: Las tasas de morbilidad en la provincia estuvieron entre 45,2 y 58,2 por 10 000 habitantes. Los municipios de mayor riesgo resultaron Matanzas y Limonar. La mayoría de las lesiones no intencionales ocurrieron en el hogar, las caídas fueron las más frecuentes y provocaron lesiones leves. Conclusiones: Las lesiones no intencionales constituyen un problema de salud. Es necesario evaluar y controlar los factores de riesgo en los distintos tipos de accidentes para prevenir o disminuir su incidencia a través de estrategias de información, educación y comunicación. Lograr que las familias estén conscientes de la vulnerabilidad de los niños es un factor esencial y básico en todos los esfuerzos que tengan como objetivo la prevención de las lesiones no intencionales en esta etapa de la vida(AU)

Introduction: Unintentional injuries are considered a health concern worldwide. Their rates rise drastically. In Cuba, they occupy one of the leading causes of morbidity in pediatric age. Objective: To describe the main epidemiological characteristics of unintentional injuries in children under 18 years of age in Matanzas. Methods: A descriptive study was carried out in Matanzas, between 2013 and 2018. The universe consisted of 4464 unintentional injuries experienced, during the period analyzed, by children under 18 years of age. Crude rates per 10 000 inhabitants were used for the analysis of the variables. Results: The morbidity rates in the province were between 45.2 and 58.2 per 10 000 inhabitants. The municipalities with the highest risk were Matanzas and Limonar. Most of the unintentional injuries occurred at home. Falls were the most frequent and caused minor injuries. Conclusions: Unintentional injuries constitute a health concern. It is necessary to assess and control the risk factors for the different types of accidents, in order to prevent or reduce their incidence, through information, education and communication strategies. Making families aware of the vulnerability of children is an essential and basic aspect in all efforts aimed at preventing unintentional injuries at this stage of life(AU)

Group 5 ITI Consensus Report: Digital technologies.

OBJECTIVES: Working Group 5 was assigned the task to review the current knowledge in the area of digital technologies. Focused questions on accuracy of linear measurements when using CBCT, digital vs. conventional implant planning, using digital vs. conventional impressions and assessing the accuracy of static computer-aided implant surgery (s-CAIS) and patient-related outcome measurements when using s-CAIS were addressed. MATERIALS AND METHODS: The literature was systematically searched, and in total, 232 articles were selected and critically reviewed following PRISMA guidelines. Four systematic reviews were produced in the four subject areas and amply discussed in the group. After emendation, they were presented to the plenary where after further modification, they were accepted. RESULTS: Static computer-aided surgery (s-CAIS), in terms of pain & discomfort, economics and intraoperative complications, is beneficial compared with conventional implant surgery. When using s-CAIS in partially edentulous cases, a higher level of accuracy can be achieved when compared to fully edentulous cases. When using an intraoral scanner in edentulous cases, the results are dependent on the protocol that has been followed. The accuracy of measurements on CBCT scans is software dependent. CONCLUSIONS: Because the precision intraoral scans and of measurements on CBCT scans and is not high enough to allow for the required accuracy, s-CAIS should be considered as an additional tool for comprehensive diagnosis, treatment planning, and surgical procedures. Flapless s-CAIS can lead to implant placement outside of the zone of keratinized mucosa and thus must be executed with utmost care.

Atorvastatin for high-risk statin-naïve patients undergoing noncardiac surgery: The Lowering the Risk of Operative Complications Using Atorvastatin Loading Dose (LOAD) randomized trial.

Preliminary evidence suggests that statins may prevent major perioperative vascular complications. METHODS: We randomized 648 statin-naïve patients who were scheduled for noncardiac surgery and were at risk for a major vascular complication. Patients were randomized to a loading dose of atorvastatin or placebo (80 mg anytime within 18hours before surgery), followed by a maintenance dose of 40 mg (or placebo), started at least 12hours after the surgery, and then 40 mg/d (or placebo) for 7days. The primary outcome was a composite of all-cause mortality, nonfatal myocardial injury after noncardiac surgery, and stroke at 30days. RESULTS: The primary outcome was observed in 54 (16.6%) of 326 patients in the atorvastatin group and 59 (18.7%) of 316 patients in the placebo group (hazard ratio [HR] 0.87, 95% CI 0.60-1.26, P=.46). No significant effect was observed on the 30-day secondary outcomes of all-cause mortality (4.3% vs 4.1%, respectively; HR 1.14, 95% CI 0.53-2.47, P=.74), nonfatal myocardial infarction (3.4% vs 4.4%, respectively; HR 0.76, 95% CI 0.35-1.68, P=.50), myocardial injury after noncardiac surgery (13.2% vs 16.5%; HR 0.79, 95% CI 0.53-1.19, P=.26), and stroke (0.9% vs 0%, P=.25). CONCLUSION: In contrast to the prior observational and trial data, the LOAD trial has neutral results and did not demonstrate a reduction in major cardiovascular complications after a short-term perioperative course of statin in statin-naïve patients undergoing noncardiac surgery. We demonstrated, however, that a large multicenter blinded perioperative statin trial for high-risk statin-naïve patients is feasible and should be done to definitely establish the efficacy and safety of statin in this patient population.

Comparação entre perímetro abdominal e índice de massa corpórea como preditores de hipertensão arterial / Comparison between waist circumference and body mass index as predictors of hypertension

A obesidade é um relevante fator de risco para desenvolvimento de hipertensão arterial. Dentre as variáveis antropométricas disponíveispara avaliação do excesso de peso, o índice de massa corpórea e a circunferência abdominal são as mais utilizadas.

Obesity is a major risk factor for the development of hypertension. Among the anthropometric variables available to measure body weight excess, the body mass index and waist circumference are the mostfrequently used.

Saúde mental de trabalhadoras do serviço de limpeza de um hospital universitário / Mental health of cleaning staff of a university hospital

Este trabalho teve como proposta analisar as percepções das trabalhadoras da zeladoria do Hospital Universitário de Maringá (HUM), com relação à sua vivência hospitalar, que permeiam a sua saúde física e mental. Tal interesse se deu pelo fato de entendermos ser este um assunto de suma importância para a preservação da saúde mental em todos os ambientes de trabalho e, especificamente, no âmbito hospitalar. A metodologia utilizada foi descritiva-exploratória. O instrumento de coleta de dados constou de um questionário baseado no modelo de Pitta (1990), que permitiu atingir os objetivos. Os resultados apontam para a necessidade de abordagens que envolvam os temas dor e morte, que possam vir a contribuir para uma boa condição de saúde mental para essas trabalhadoras